Fogmorfológiai tulajdonságok filogeográfiai összefüggései az archeogenetikai adatok fényében
Absztrakt
Among the methods belonging to the toolkit of anthropological research, dental non-metric studies investigating the morphological traits of teeth are currently one of the most common for examining the biological relationships between populations. Despite the spread of archaeogenetic analyses, a study comparing the results of genetic and dental non-metric analyses of the same individuals is unique internationally.
In order to address this hiatus, the subject of our study was the dentition of individuals from the Avar and Hungarian Conquest periods of the Carpathian Basin, for whom published whole-genome data were available. Taking advantage of this unique opportunity, the aim of the PhD thesis was to test and develop a literature-based method, and to validate this method with genetic data.
For recording the dental non-metric traits, the latest version of the widely known Arizona State University Dental Anthropology System (ASUDAS)-based method was used with minor modifications. To examine the genetic composition of the studied individuals, we performed a supervised ADMIXTURE analysis.
Our research has validated the usefulness of dental non-metric analyses for understanding the origins of past populations using genetic data. Furthermore, we have developed a method, supported by genetic data, that can be used to provide estimates of ancestry even at the individual level. Although our study has highlighted the potential of dental non-metric studies, it has also revealed methodological problems and limitations in testing methods and hypotheses that can only be overcome by extending the study material.
Hivatkozások
Adler, C.J., Haak, W., Donlon, D., Cooper, A. (2011): Survival and recovery of DNA from ancient teeth and bones. Journal of Archaeological Science, 38(5): 956–964. DOI: https://doi.org/10.1016/j.jas.2010.11.010
Alexander, D.H., Lange, K. (2011): Enhancements to ADMIXTURE algorithm for individual ancestry estimation. BMC Bioinformatics, 12: 246. DOI: hgy s://doi.org/10.1186/1471-2105-12-246
Alexander, D.H., Novembre, J., Lange, K. (2009): Fast model-based estimation of ancestry in unrelated individuals. Genome Research, 19(9): 1655–1664. DOI: https://doi.org/10.1101/gr.094052.109
Brook, A.H., Brook O’Donnell, M., Hone, A., Hart, E., Hughes, T.E., Smith, R.N., Townsend, G.C. (2014): General and craniofacial development are complex adaptive processes influenced by diversity. Australian Dental Journal, 59(S1): 13–22. DOI: https://doi.org/10.1111/adj.12158
Carson, E.A. (2006): Maximum likelihood estimation of human craniometric heritabilities. American Journal of Physical Anthropology, 131(2): 169–180. DOI: https://doi.org/10.1002/ajpa.20424
Chowdhry, A., Popli, D.B., Sircar, K., Kapoor, P. (2023): Study of twenty non metric dental crown traits using ASUDAS system in NCR (India) population. Egyptian Journal of Forensic Sciences, 13(8): 1–12. DOI: https://doi.org/10.1186/s41935-023-00329-2
Dahlberg, A.A. (1945): The changing dentition of man. Journal of the American Dental Association, 32(11): 676–690. DOI: https://doi.org/10.14219/jada.archive.1945.0112
Dahlberg, A.A. (1951): The dentition of the American Indian. In: Laughlin, W.S. (Ed.) Physical Anthropology of the American Indian. Viking Fund Inc., New York, USA. pp. 138–176.
Dern, L.L. (2023): The Impact of Medieval and Early Modern Migrations on Dental Nonmetric Variation in Hungary. PhD dissertation. University of Nevada, Reno, USA.
Gáll, E. (2019): A hatalom forrása és a magyar honfoglalás, hódítás és integráció. A korai magyar történelem egy régész szemszögéből. Magyarságkutató Intézet, Budapest.
Gnecchi-Ruscone, G.A., Szécsényi-Nagy, A., Koncz, I., Csiky, G., Rácz, Zs., Rohrlach, A.B., Brandt, G., Rohland, N., Csáky, V., Cheronet, O., Szeifert, B., Rácz, T. Á., Benedek, A., Bernert, Zs., Berta, N., Czifra, S., Dani, J., Farkas, Z., Hága, T., Hajdu, T., Jászberényi, M., Kisjuhász, V., Kolozsi, B., Major, P., Marcsik, A., Ny. Kovacsóczy, B., Balogh, Cs., Lezsák, G.M., Ódor, J.G., Szelekovszky, M., Szeniczey, T., Tárnoki, J., Tóth, Z., Tutkovics, E.K., Mende, B.G., Geary, P., Pohl, W., Vida, T., Pinhasi, R., Reich, D., Hofmanová, Z., Jeong, C., Krause, J. (2022): Ancient genomes reveal origin and rapid trans-Eurasian migration of 7th century Cell, 185(8): 1402–1413. DOI: https://doi.org/10.1016/j.cell.2022.03.007
Hillson, S. (1996): Dental Anthropology. Cambridge University Press, Cambridge, UK.
Hubbard, A.R., Guatelli-Steinberg, D., Irish, J.D. (2015): Do nuclear DNA and dental nonmetric data produce similar reconstructions of regional population history? An example from modern coastal Kenya. American Journal of Physical Anthropology, 157(2): 295–304. DOI: https://doi.org/10.1002/ajpa.22714
Hubbard, A.R. (2012): An examination of population history, population structure, and biological distance among regional populations of the kenyan coast using genetic and dental data. PhD dissertation. Ohio State University, USA.
Irish, J.D., Morez, A., Girdland Flink, L., Phillips, E.L.W., Scott, G.R. (2020): Do dental nonmetric traits actually work as proxies for neutral genomic data? American Journal of Physical Anthropology, 172(3): 347–375. DOI: https://doi.org/10.1002/ajpa.24052
Jorsboe, E., Hanghoj, K., Albrechtsen, A. (2017): fastNGSadmix: admixture proportions and principal component analysis of a single NGS sample. Bioinformatics, 33(19): 3148–3150. DOI: https://doi.org/10.1093/bioinformatics/btx474
Keene, H.J. (1968): The relationship between Carabelli’s trait and the size, number and morphology of the maxillary molars. Archives of Oral Biology, 13(8): 1023–1025. DOI: https://doi.org/10.1016/0003-9969(68)90018-6
Kocsis-Savanya, G., Marcsik, A. (1981): Zománcképződmények a VII-VIII. századból származó koponyák fogain. Fogorvosi Szemle, 74: 89–93.
Kocsis-Savanya, G. (1993): Ásatási leletekből származó maradandó frontfogak makromorfológiai fejlődési rendellenességeinek jellemzői és azok előfordulási gyakorisága. Kandidátusi értekezés. Szeged.
Kocsis-Savanya, G. (1994): Ásatási leletekből származó maradandó frontfogak makromorfológiai fejlődési rendellenességeinek jellemzői és azok előfordulási gyakorisága. Anthropologiai Közlemények, 36: 85–95.
Lazaridis, I., Alpaslan-Roodenberg, S., Acar, A., Acikkol, A., Agelarakis, A., Aghikyan, L., Akyuz, U., Andreeva, D., Andrijašević, G., Antonovic, D., Armit, I., Atmaca, A., Avetisyan, P., Aytek, A.I., Bacvarov, K., Badalyan, R., Bakardzhiev, S., Balen, J., Bejko, L., Bernardos, R., Bertsatos, A., Biber, H., Bilir, A., Bodružić, M., Bonogofsky, M., Bonsall, C., Boric, D., Borovinic, N., Bravo Morante, G., Buttinger, K., Callan, K., Candilio, F., Caric, M., Cheronet, O., Chohadzhiev, S., Chovalopoulou, M-E., Chryssoulaki, S., Ciobanu, I., Kondic, N., Constantinescu, M., Cristiani, E., Culleton, B. J., Curtis, E., Davis, J., Davtyan, R., Demcenco, T.I., Dergachev, V., Derin, Z., Deskaj, S., Devejyan, S., Djordjevic, V., Duffett Carlson, K.S., Eccles, L.R., Elenski, N., Engin, A., Erdogan, N., Erir-Pazarci, S., Fernandes, D.M., Ferry, M., Freilich, S., Frinculeasa, A., Galaty, M.L., Gamarra, B., Gasparyan, B., Gaydarska, B., Genç, E., Gültekin, T., Gündüz, S., Hajdu, T., Heyd, V., Hobosyan, S., Hovhannisyan, N., Iliev, I., Iliev, L., Iliev, S., Ivgin, I., Jankovic, I., Jovanova, L., Karkanas, P., Kavaz-Kindigili, B., Kaya, E.H., Keating, D., Kennett, D.J., Deniz Kesici, S., Khudaverdyan, A., Kiss, K., Kiliç, S., Klostermann, P., Kostak Boca Negra Valdes, S., Kovacevic, S., Krenz-Niedbała, M., Krznaric Skrivanko, M., Kurti, R., Kuzman, P., Lawson, A.M., Lazar, C., Leshtakov, K., Reich, D. (2022): The genetic history of the Southern Arc: A bridge between West Asia and Europe. Science, 377(6609). DOI: https://doi.org/10.1126/science.abm4247
Lazaridis, I., Patterson, N., Mittnik, A., Renaud, G., Mallick, S., Kirsanow, K., Sudmant, P. H., Schraiber, J.G., Castellano, S., Lipson, M., Berger, B., Economou, C., Bollongino, R., Fu, Q., Bos, K.I., Nordenfelt, S., Li, H., de Filippo, C., Prüfer, K., Sawyer, S., Posth, C., Haak, W., Hallgren, F., Fornander, E., Rohland, N., Delsate, D., Francken, M., Guinet, J-M., Wahl, J., Ayodo, G., Babiker, H. A., Bailliet, G., Balanovska, E., Balanovsky, O., Barrantes, R., Bedoya, G., Ben-Ami, H., Bene, J., Berrada, F., Bravi, C. M., Brisighelli, F., Busby, G. B.J., Cali, F., Churnosov, M., Cole, D.E.C., Corach, D., Damba, L., van Driem, G., Dryomov, S., Dugoujon, J-M., Fedorova, S.A., Gallego Romero, I., Gubina, M., Hammer, M., Henn, B.M., Hervig, T., Hodoglugil, U., Jha, A.R., Karachanak-Yankova, S., Khusainova, R., Khusnutdinova, E., Kittles, R., Kivisild, T., Klitz, W., Kucinskas, V., Kushniarevich, A., Laredj, L., Litvinov, S., Loukidis, T., Mahley, R. W., Melegh, B., Metspalu, E., Molina, J., Mountain, J., Nakkalajarvi, K., Nesheva, D., Nyambo, T., Osipova, L., Parik, J., Platonov, F., Posukh, O., Romano, V., Rothhammer, F., Rudan, I., Ruizbakiev, R., Sahakyan, H., Sajantila, A., Salas, A., Starikovskaya, E.B., Tarekegn, A., Toncheva, D., Turdikulova, S., Uktveryte, I., Utevska, O., Vasquez, R., Villena, M., Voevoda, M., Krause, J. (2014): Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature, 513(7518): 409–413. DOI: https://doi.org/10.1038/nature13673
Maczel, M., Kocsis-Savanya, G., Marcsik, A., Molnár, E. (1998): Dental disease in the Hungarian conquest period. Bulletins et Mémoires de la Société d’anthropologie de Paris, 10(3): 457–470. DOI: https://doi.org/10.3406/bmsap.1998.2530
Maróti, Z., Neparáczki, E., Schütz, O., Maár, K., Varga, G. I. B., Kovács, B., Kalmár, T., Nyerki, E., Nagy, I., Latinovics, D., Tihanyi, B., Marcsik, A., Pálfi, Gy., Bernert, Zs., Gallina, Zs., Horváth, C., Varga, S., Költő, L., Raskó, I., Nagy, P.L., Balogh, Cs., Zink, A., Maixner, F., Götherström, A., George, R., Szalontai, Cs., Szenthe, G., Gáll, E., Kiss, A.P., Gulyás, B., Kovacsóczy, B.Ny., Gál, S. S., Tomka, P., Török, T. (2022): The genetic origin of Huns, Avars, and conquering Hungarians. Current Biology, 32(13): 2858–2870.e7. DOI: https://doi.org/10.1016/j.cub.2022.04.093
Pilloud, M.A., Kenessey, D.E., Vlemincq-Mendieta, T., Scott, G.R., Philbin, C.S. (2022): Dentabase User Manual v2.3. Reno: University of Nevada.
R Core Team (2021): R: A Language and Environment for Statistical Computing. Vienna, Ausztria. https://www.R-project.org/
Raffone, C., Baeta, M., Lambacher, N., Granizo-Rodriguez, E., Etxeberria, F., de Pancorbo, M. M. (2021): Intrinsic and extrinsic factors that may influence DNA preservation in skeletal remains: A review. Forensic Science International, 325: 110859. DOI: https://doi.org/10.1016/j.forsciint.2021.110859
Rathmann, H., Reyes-Centeno, H., Ghirotto, S., Creanza, N., Hanihara, T., Harvati, K. (2017): Reconstructing human population history from dental phenotypes. Scientific Reports, 7(1): 12495. DOI: https://doi.org/10.1038/s41598-017-12621-y
Rathmann, H., Reyes-Centeno, H. (2020): Testing the utility of dental morphological trait combinations for inferring human neutral genetic variation. Proceedings of the National Academy of Sciences, 117(20): 10769–10777. DOI: https://doi.org/10.1073/pnas.1914330117
Révész, L. (2014): The Era of the Hungarian Conquest. Hungarian National Museum, Budapest.
Roseman, C.C. (2004): Detecting interregionally diversifying natural selection on modern human cranial form. Proceedings of the National Academy of Sciences, 101(35): 12824–12829. DOI: https://doi.org/10.1073/pnas.0402637101
Sawyer, S., Renaud, G., Viola, B., Hublin, J-J., Gansauge, M-T., Shunkov, M.V., Derevianko, A.P., Prüfer, K., Kelso, J., Paabo, S. (2015): Nuclear and mitochondrial DNA sequences from two Denisovan individuals. Proceedings of the National Academy of Sciences, 112(51): 15696–15700. DOI: https://doi.org/10.1073/pnas.1519905112
Scott, G. R. (1977a): Classification, Sex Dimorphism, Association, and Population Variation of the Canine Distal Accessory Ridge. Human Biology, 49(3): 453–469.
Scott, G. R. (1977b): Interaction Between Shoveling of the Maxillary and Mandibular Incisors. Journal of Dental Research, 56(11): 1423–1423. DOI: https://doi.org/10.1177/00220345770560112701
Scott, G.R. (1979): Association Between the Hypocone and Carabelli’s Trait of the Maxillary Molars. Journal of Dental Research, 58(4): 1403–1404. DOI: https://doi.org/10.1177/00220345790580041701
Scott, G.R., Dern, L.L., Evinger, S., O’Rourke, D.H., Hoffecker, J.F. (2022): Multiple occurrences of the rare Uto‐Aztecan premolar variant in Hungary point to ancient ties between populations of western Eurasia and the Americas. International Journal of Osteoarchaeology, 32(5): 1096–1104. DOI: https://doi.org/10.1002/oa.3135
Scott, G.R., Irish, J.D. (2017): Human Tooth Crown and Root Morphology The Arizona State University Dental Anthropology System. Cambridge University Press, Cambridge, UK.
Scott, G.R., O’Rourke, D.H., Raff, J.A., Tackney, J.C., Hlusko, L.J., Elias, S.A., Bourgeon, L., Potapova, O., Pavlova, E., Pitulko, V., Hoffecker, J. F. (2021): Peopling the Americas: Not “Out of Japan”. PaleoAmerica, 7(4): 309–332. DOI: https://doi.org/10.1080/20555563.2021.1940440
Scott, G. R., Turner, C. G. II., Townsend, G. C., Martinón-Torres, M. (2018): The Anthropology of Modern Human Teeth Dental Morphology and its Variation in Recent and Fossil Homo sapiens. 2. kiadás. Cambridge: Cambridge University Press.
Stojanowski, C. M., Paul, K. S., Seidel, A. C., Duncan, W. N., Guatelli-Steinberg, D. (2018): Heritability and genetic integration of anterior tooth crown variants in the South Carolina Gullah. American Journal of Physical Anthropology, 167(1): 124–143.
Stojanowski, C. M., Paul, K. S., Seidel, A. C., Duncan, W. N., Guatelli‐Steinberg, D. (2019): Quantitative genetic analyses of postcanine morphological crown variation. American Journal of Physical Anthropology, 168(3): 606–631. DOI: https://doi.org/10.1002/ajpa.23778
Szeniczey, T. (2019): A Kelet-Dunántúl avar kori népességváltozásainak történeti embertani vizsgálata. Doktori értekezés. Eötvös Loránd Tudományegyetem, Budapest.
Townsend, G., Harris, E. F., Lesot, H., Clauss, F., Brook, A. (2009): Morphogenetic fields within the human dentition: A new, clinically relevant synthesis of an old concept. Archives of Oral Biology, 54(1): S34–S44.
Turner, C.G., Nichol, C.R., Scott, G.R. (1991): Scoring procedures for key morphological traits of the permanent dentition: the Arizona State University Dental Anthropology System. Advances in Dental Anthropology, 13–31.
Vida, T. (2008): Conflict and Coexistence: The Local Population of the Carpathian Basin underAvar rule (6th to 7th century). In Curta, F., Kovalev, R. (Eds) The Other Europe in the Middle Ages: Avars, Bulgars, Khazars and Cumans. Leiden, Brill. pp. 13–46.
Wright, J.T. (2023): Enamel Phenotypes: Genetic and Environmental Determinants. Genes, 14(3): 545. DOI: https://doi.org/10.3390/genes14030545
Yang, G., Chen, Y., Li, Q., Benítez, D., Ramírez, L.M., Fuentes-Guajardo, M., Hanihara, T., Scott, G.R., Alonzo, V.A., Jose, R. G., Bortolini, M.C., Poletti, G., Gallo, C., Rothhammer, F., Rojas, W., Zanolli, C., Adhikari, K., Ruiz-Linares, A., Delgado, M. (2023): Dental size variation in admixed Latin Americans: Effects of age, sex and genomic ancestry. PLOS ONE, 18(5): e0285264. DOI: https://doi.org/10.1371/journal.pone.0285264
